Textbooks
 |
Physical Biology of
the Cell (2nd ed) ISBN: 0815344503 |
|
Cell Biology by the Numbers This book is in the final stages of completion and will be published at the end of 2015. You can find the most current draft here. Several readings will be assigned from this book as part of the homework. |
| DATE | TOPIC | READINGS DISCUSSED IN CLASS | HOMEWORK |
| Monday, Jan. 5 | Lecture 1: Course introduction, biological numeracy and discoveries about the living world, A feeling for the numbers part 1. E. coli by the numbers. | Streetfighting Mathematics
The End of Theory: The Data Deluge Makes the Scientific Method Obsolete Nature 1902 |
|
| Wednesday, Jan. 7 | Lecture 2: A feeling for the numbers part 2. Rates in the central dogma, diffusion and diffusive time scales, flies by the numbers. | Superresolution Imaging of Ribosomes and RNA Polymerase in live E. coli cells
Drosophila Brainbow Li et. al. 2014 Gregor et. al. 2007 |
HW1 out |
| Friday, Jan. 9 | Lecture 3: Wetware! Biological computation. Examples including enzymes, ion channels and transcription factors. Statistical mechanics of binding. | ||
| Monday, Jan. 12 | Lecture 4: Immunological computation. Chemotaxis part 1. | ||
| Wednesday, Jan. 14 | Lecture 5: Chemotaxis part 2. | HW1 due HW2 out | |
| Friday, Jan. 16 | Lecture 6: The Monod-Wyman-Changeux model and enzyme action. | ||
| Monday, Jan. 19 | no class, MLK day | ||
| Wednesday, Jan. 21 | Lecture 7: MWC enzymes, bioelectricity and light. Cell signaling and statistical mechanics. | Bray ; Sourjik | HW2 due HW3 out |
| Friday, Jan. 23 | Lecture 8: Introduction to gene expression. | ||
| Monday, Jan. 26 | Lecture 9: Gene expression in bacteria | ||
| Wednesday, Jan. 28 | Lecture 10: Gene expression in development of multicellular organisms | HW3 due HW4 out | |
| Friday, Jan. 30 | Lecture 11: Biological order in one-, two- and three-dimension. Biological polymerization and biological fidelity. | Howard,Grill,Bois review | |
| Monday, Feb. 2 | no class, RP out of town | ||
| Wednesday, Feb. 4 | no class, RP out of town | HW4 due HW5 out | |
| Friday, Feb. 6 | no class, RP out of town | ||
| Monday, Feb. 9 | Lecture 12: The cytoskeleton, part 1. | ||
| Wednesday, Feb. 11 | Lecture 13: The cytoskeleton, part 2. How are cytoskeletal lengths controlled. | Frank | HW5 due HW6 out |
| Friday, Feb. 13 | no class, RP out of town | ||
| Monday, Feb. 16 | no class, President's Day | ||
| Wednesday, Feb. 18 | Lecture 14: chromosome geography and ordering the DNA. | HW6 due No HW this week | |
| Friday, Feb. 20 | Lecture 15: organization at membranes | ||
| Monday, Feb. 23 | Lecture 16: organization of cells - organellar structure and size control, multicellular structures | ||
| Wednesday, Feb. 25 | Lecture 17: Special Lecture: Adventure in Science | HW7 out | |
| Thursday, Feb. 26 | Lecture 18: Thursday evening, pizza dinner and make up lecture - special lecture on evolution and population genetics, physical biology at larger space and time scales. Is the earth old? Is the earth big? | ||
| Friday, Feb. 27 | Lecture 19: Last day of class. Course summary and what we want you to remember. | Hologenomic Basis | |
| Friday, Mar. 6 | HW7 due |